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No particular dose adjustment suggested when tofacitinib coadministered with powerful CYP2C19 inhibitors; lower tofacitinib dose if coadministered with both moderate CYP3A4 and strong CYP2C19 inhibitors .Hou et al (2005) analyzed the autonomic outcomes of modafinil in human beings. They discovered that modafinil influences the locus coeruleus, whic